MITIN is proposing to elucidate the interplay between the insulin signaling pathway and the mitochondrial function

Expected Achievements

• Identify new signalling pathways that regulate mitochondrial function and biogenesis, and elucidate the precise molecular mechanism that mediate this process.

• Determine the impact of alterations in mitochondrial function driven by changes in the expression of proteins involved in mitochondrial dynamics or in the expression of nuclear co-activators on insulin sensitivity.

• Identify potential new targets for the development of future therapeutic strategies towards insulin resistance related diseases.

• Demonstrate the suitability of a System Biology methodological approach for studying complex biological processes and for identifying new drug targets.

• Develop technologies and tools for System Biology computational framework development that enable the further study of other Complex Diseases