MITIN is proposing to elucidate the interplay between the insulin signaling pathway and the mitochondrial function

Publications

PUBLICATIONS 

  • Cho Cho Aye, Mary Doherty, Chenjing Yang, Xiaoxin Li, Philip Whitefield, Antonio Zorzano and Silvia Mora. Casitas b- lymphoma is required for normal mitochondrial function in C2C12 myocytes. In preparation.
  • Identification of novel type 2 diabetes candidate genes involved in the mitochondria-insulin systems crosstalk through systems biology-guided GWAS analyses. Josep M Mercader, Montserrat Puiggros, Evarist Planet, Eleonora M. Sorianello, David Sebastian, Sergio Rodriguez-Cuenca, Vicent Ribas, Sorin Draghici, Chenjing Yang, Sílvia Mora, Antoni Vidal-Puig, Antonio Zorzano, David Torrents. In preparation.
  • Xiaojun Xu, Peddinti Gopalacharyullu, Tuulikki SeppanenLaakso, Cho Cho Aye, Silvia Mora, Matej Oresic and Aurelio Teleman. Insulin signaling regulates fatty acid catabolism at the level of Coa A activation. Journal submitted to Plus Genetics. Journal submitted to Plus Genetics.
  • Chenjing Yang, Xiaoxin Li, Cho Cho Aye, Ma Angels Diaz, Antonio Zorzano and Silvia Mora. Defects in insulin signaling and saturated fatty acid exposure cause mitochondrial dysfunction via distinct mechanisms. Manuscript submitted to Cellular and Molecular endocrinology. Manuscript submitted to Cellular and Molecular endocrinology.
  • Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A, Huang CL. Deletion of the metabolic transcriptional coactivator PGC1{beta} induces cardiac arrhythmia. Cardiovasc Res. 2011 Oct 1;92(1):29-38.
  • Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci. 2011 Jul 1;124(Pt 13):2143-52. Epub 2011 May 31.PMID:21628424.
  • E. Lindfors, J. Mattila, P. V. Gopalacharyulu, A. Pesonen, J. Lötjönen, M. Orešič, Heterogeneous biological network visualization system: case study in context of medical image data, Adv. Exp. Med. Biol. (2011, in press).
  • H. Nygren, T. Seppänen-Laakso, S. Castillo, T. Hyötyläinen, M. Orešič, Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues, Methods Mol. Biol. 708, 247-257 (2011).
  • Linglin Xie, M. Teresa Ortega, Silvia Mora, and Stephen K. Chapes: Interactive changes between macrophages and adipocytes ,Clinical Vaccine and Immunology, American Society for microbiology, [s.l.] February 2010, volume 17, 651-9 p.
  • Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP: Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice, Free Radic Biol Med, Elsevier Inc., New York, January 2010, nº48(1), 161-72 p.
  • Zorzano A, Hernández-Alvarez MI, Palacín M, Mingrone G.: Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes, Biochimica et Biophysica Acta, Elsevier Inc., New York, January 2010, nº1797, 1028-1033 p.
  • Antonio Zorzano, Marc Liesa, David Sebastian, Jessica Segalés, Manuel Palacín: Mitochondrial fusion proteins: Dual regulators of morphology and metabolism, Seminars in Cell & Developmental Biology 2010 Aug;21(6), 566-575 p.
  • Zorzano A, Sebastián D, Segalés J, Palacín M. The molecular machinery of mitochondrial fusion and fission: An opportunity for drug discovery? Curr Opin Drug Discov Devel. 2009 Sep;12(5):597-606. Review.PMID:19736619.).
  • Zorzano A, Liesa M, Palacín M. Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes.Int J Biochem Cell Biol. 2009 Oct;41(10):1846-54. Epub 2009 Feb 20. Review. PMID:19703653.).
  • Zorzano A, Liesa M, Palacín M. Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance. Arch Physiol Biochem. 2009 Feb;115(1):1-12. Review. PMID:19267277.).
  • Liesa M, Palacín M, Zorzano A. Mitochondrial dynamics in mammalian health and disease. Physiol Rev. 2009 Jul;89(3):799-845. Review. PMID:19584314.).
  • P. S. Niemelä, S. Castillo, M. Sysi-Aho, M. Orešič, Bioinformatics and computational strategies for lipidomics, J. Chromatogr. B 877, 2855-2862 (2009).
  • Chenjing Yang, Xiaoxin Li, Cho Cho Aye, Ma Angels Diaz, Antonio Zorzano and Silvia Mora. Defects in insulin signaling and saturated fatty acid exposure cause mitocondrial dysfunction via distinct mechanisms. Manuscript in preparation.
  • Xiaojun Xu, Peddinti Gopalacharyullu, Tuulikki SeppanenLaakso, Cho Cho Aye, Silvia Mora, Matej Oresic and Aurelio Teleman. Insulin signaling regulates fatty acid catabolism at the level of Coa A activation. Manuscript in preparation.
  • Antonio Zorzano, Marc Liesa, David Sebastián, Jessica Segalés, Manuel Palacín Mitochondrial fusion proteins: Dual regulators of morphology and metabolism Seminars in Cell & Developmental Biology 21 (2010) 566–574
  • I. Mattila, T. Seppänen-Laakso, T. Suortti, M. Orešič, Application of lipidomics and metabolomics to the study of adipose tissue, Methods Mol. Biol. 456, 123-130 (2008).
  • Liesa M, Borda-d'Agua B, Medina-Gómez G, Lelliott CJ, Paz JC, Rojo M, Palacín M, Vidal-Puig A, Zorzano A. Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One. 2008;3(10):e3613. Epub 2008 Oct 31. PMID:18974884.
  • Parra V, Eisner V, Chiong M, Criollo A, Moraga F, Garcia A, Härtel S, Jaimovich E, Zorzano A, Hidalgo C, Lavandero S. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis.Cardiovasc Res. 2008 Jan 15;77(2):387-97. Epub 2007 Oct 4. PMID:18006463.