Dr. Aurelio Teleman
Contact e-mail
a.teleman
dkfz.de
Background
Aurelio Teleman is a Junior Group Leader in the Functional Genomics Department at the German Cancer Research Center (DKFZ) in Heidelberg, Germany. Before becoming group leader, he worked with Steve Cohen at the European Molecular Biology Laboratory (EMBL) using Drosophila to study genes regulating tissue growth and organismal metabolism.
The Teleman lab currently focuses on insulin signaling, a central regulator of tissue growth and metabolism in animals. Insulin signaling controls these processes in part via the regulation of cellular transcription. In the past, we used a combination of genetic and genomic techniques (expression profiling and ChIP/chip) to study the transcriptional output of insulin signaling, and to map how insulin signaling connects to the transcriptional machinery of the cell. Furthermore, we studied in detail some flies mutant for insulin signaling components. This background will be brought to bear in the MITIN project, studying how insulin signaling regulates mitchondrial function and vice-versa.
Selected publications
- Teleman AA, Hietakangas V, Sayadian AC, Cohen SM. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. (2008) Cell Metabolism. 7:21-32.
- Teleman AA and Cohen SM. Drosophila lacking microRNA miR-278 are defective in energy homeostasis. (2006) Genes Dev 20:417-2
- Teleman AA, Chen YW, Cohen SM. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. (2005) Genes Dev 19:1844-8
- Teleman AA, Chen YW, Cohen SM. Drosophila melted modulates FOXO and TOR activity. (2005) Dev Cell 9:271-81
Research Group's Website
